P09 - Functional role of TRP channels in neuroendocrine cells of the brain
TRP channels are molecular candidates for hormone-operated cation channels in neuroendocrine cells of the brain. Hormones have been reported to influence TRP channels and their expression. Conversely, TRP channel activation can influence hormonal release. This kind of cross talk between hormones and TRP channels could have profound effects on influencing reproductive physiology as well as on altering specific diseases. This proposal will furnish the first description of TRPC5 interaction in particular hypothalamic neurons, provide valuable insights into the mechanisms of TRPC5 activation, and offer a unique opportunity to examine the role of TRPC5 in hormonal control.