Transregional Collaborative Research Centre 152

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P10 - Novel TRP channel functions in olfaction

The overall goal of this project is to test the proposal that, besides TRPC2, additional TRP channels play important functional roles in neuronal processing and homeostatic regulation of the mammalian olfactory system. We will focus initially on two Ca2+-activated cation channels whose precise function in the nervous system is not well understood: TRPM4 and TRPM5. We will employ novel mouse strains in which these channels are genetically traceable to define the extent of their expression in olfactory subsystems and determine the function of these channels in olfactory neuronal populations.

Frank Zufall

Prof. Dr. Frank Zufall

Saarland University

+49 6841 16 26450