P19 - Exploring the pharmacology and photopharmacology of TRP channels
In close collaboration with P18, the objective of this research is to synthesize small molecules that interact with TRP channels, in particular TRPC3, TRPC5, TRPC6, TRPM1, TRPM7, TRPM8, and TRPV1. One goal is to develop photochromic agonists and antagonists. These molecules could be used to control TRP channels with the temporal and spatial precision. In addition, we will provide synthetic support to the CRC and explore the pharmacology of TRP channels in close collaboration with other members of the consortium. A total synthesis of novel TRP-inhibitor is proposed. The synthetic derivatives obtained in the course of this effort will be tested for their ability to block TRP channels.
Figure. Taking advantage of our expertise in natural product synthesis, we are working on the synthesis of marine natural products as potent blockers of TRP channels.