Transregional Collaborative Research Centre 152
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Curriculum Vitae

Advanced Professional Positions

  • 2011 – present Group Leader, LMU Munich, Department Pharmazie – Zentrum für Pharma-Forschung, Pharmakologie für Naturwissenschaften, Advisor: Martin Biel
  • 2009 – 2011 Group Leader, Principal Scientist, Pain Research Unit – Discovery Biology, Pfizer Global R&D, Sandwich, Kent, UK

Professional Experience and Postdoctoral Training

  • 2005 – 2009 Postdoctoral Fellow, Department of Otolaryngology Head & Neck Surgery and Molecular & Cellular Physiology, Stanford University, CA, USA, Advisor: Stefan Heller
  • 2004 – 2005 Postdoctoral Fellow, Department of Otolaryngology and Program in Neuroscience, Massachusetts Eye & Ear Infirmary, Harvard University, Boston, MA, USA, Advisor: Stefan Heller

Academic Education

  • 2015 Habilitation (Pharmacology), LMU Munich, Mentor: Martin Biel
  • 2011 Dr. phil., Universität Kassel and Max-Planck-Institute for the History of Science, Berlin, Mentors: Kristian Köchy (Kassel), Hans-Jörg Rheinberger, Director MPI History of Science, Berlin)
  • 2004 Dr. rer. nat., Institut für Pharmakologie der Medizin, Freie Universität Berlin, Mentors: Günter Schultz/Christian Harteneck)
  • 1995 – 2000 Study of Pharmacy, Julius-Maximilians-Universität, Würzburg

Honours, Awards, Scholarships and Other Qualifications

  • 2005 Ernst-Reuter Award, Freie Universität Berlin (best doctoral thesis 2004)

Professional Activities, Memberships

  • 2001 – 2004 Graduate research, Institute of Pharmacology, Freie Universität Berlin, Supervisor: Günter Schultz
  • 2000 Internship, Pharmaceutical R&D, Bayer AG, Leverkusen, Germany

 Publications

  • Grimm C, Jörs S, Gao Z, Obukhov AG, Heller S. Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules. J Biol Chem 287:22701-22708, 2012.
  • Aneiros E, Cao L, Papakosta M, Stevens EB, Phillips SC, Grimm C. Biophysical and molecular basis of TRPV1 proton gating. EMBO J 30:994-1002, 2011.
  • Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S. Small molecule activators of TRPML3. Chem Biol 17:135-148, 2010.
  • Grimm C, Jörs S, Heller S. Life and death of sensory hair cells expressing constitutively active TRPML3. J Biol Chem 284:13823-13831, 2009.
  • Grimm C, Cuajungco MP, van Aken AFJ., Schnee M, Jörs S, Kros CJ, Ricci AJ, Heller S. A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. Proc Natl Acad Sci USA 104:19583-19588, 2007.
  • Grimm, C., Holdt, L.M., Chen, C.-C., Hassan, S., Müller, C., Jörs, S., Cuny, H., Kissing, S., Schröder, B., Butz, E., Northoff, B., Castonguay, J., Luber, C.A., Moser, M., Spahn, S., Lüllmann-Rauch, R., Fendel, C., Klugbauer, N., Griesbeck, O., Haas, A., Mann, M., Bracher, F., Teupser, D., Saftig, P., Biel, M., Wahl-Schott, C. (2014) High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nature Commun., 5:4699. doi: 10.1038/ncomms5699
  • Cuajungco, M.P., Basilio, L.C., Silva, J., Hart, T., Tringali, J., Chen, C.-C., Biel, M., Grimm, C.# (2014) Cellular zinc levels are modulated by TRPML1-TMEM163 interaction. Traffic, doi: 10.1111/tra.12205. [Epub ahead of print]
  • Chen, C.-C.,Keller, M., Hess, M., Schiffmann, R., Urban, N., Wolfgardt, A., Schaefer, M., Bracher, F., Biel, M., Wahl-Schott, C., Grimm, C.# (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature Commun., 5:4681. doi: 10.1038/ncomms5681