Transregional Collaborative Research Centre 152
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Curriculum Vitae

Advanced Professional Position

  • 2018 - present Associate Professor (tenure-track, W2), Department of Pharmacology and Toxicology, Faculty of Medicine, LMU München, Germany
  • 2015 – 2018 “Privatdozent” (Assistant Professor eq.) and independent Group Leader, Department of Pharmacology, Faculty of Chem. & Pharm., LMU München, Germany
  • 2011 – 2015  Lecturer (“Habilitand”) and independent Group Leader, Department of Pharmacology, Faculty of Chem. & Pharm., LMU München, Germany (Prof. Dr. Martin Biel)
  • 2009 – 2011 Group Leader, Principal Scientist, Pain Research Unit – Discovery Biology, Pfizer Global R&D, Sandwich, Kent, UK

Professional Experience and Postdoctoral Training

  • 2005 – 2009 Postdoctoral Fellow, Department of Otolaryngology Head & Neck Surgery and Molecular & Cellular Physiology, Stanford University, CA, USA, Advisor: Stefan Heller
  • 2004 – 2005 Postdoctoral Fellow, Department of Otolaryngology and Program in Neuroscience, Massachusetts Eye & Ear Infirmary, Harvard University, Boston, MA, USA, Advisor: Stefan Heller

Academic Education

  • 2015 Habilitation (Pharmacology), LMU Munich, Mentor: Martin Biel
  • 2011 Dr. phil., Universität Kassel and Max-Planck-Institute for the History of Science, Berlin, Mentors: Kristian Köchy (Kassel), Hans-Jörg Rheinberger, Director MPI History of Science, Berlin)
  • 2004 Dr. rer. nat., Institut für Pharmakologie der Medizin, Freie Universität Berlin, Mentors: Günter Schultz/Christian Harteneck)
  • 1995 – 2000 Study of Pharmacy, Julius-Maximilians-Universität, Würzburg

Third Party fundings, Honours, Awards, Scholarships and Other Qualifications

  • 2019-2020 DAAD (German Academic Exchange Service), Project 57448707 (Cooperation with Sui-Yuan Chang, National Taiwan University, Taipeh)
  • 2019-2020 DAAD/TRF (German Academic Exchange Service and Thailand Research Foundation), Project 57453751 (Cooperation with Prof. Wanchai De-eknamkul, Chulalongkorn University, Bangkok)
  • 2018-2021 DFG/Lung Toxicology Research Training Group GRK 2338-1 P08 (Co-PI with Martin Biel)
  • 2017 Care-for-Rare Foundation Award, LMU Munich (PI)
  • 2016-2017 University of Pennsylvania Orphan Disease Center and MLIV (Mucolipidosis type IV) Foundation Grant (MDBR-17-120-ML4) (PI)
  • 2016 NCL (Neuronal ceroid lipofuscinosis) Foundation Award (PI)
  • 2015 Fritz-Thyssen Foundation Travel Fellowship (to Geneva/CH)
  • 2013-2016 Bavarian Research Foundation Grant (DOK-154-13) (PI)
  • 2013-2014 DFG (German Research Council) Grant GR-4315/1-1 (PI)
  • 2005 Ernst-Reuter Award, Freie Universität Berlin (best doctoral thesis 2004)
  • 1994 Fonds of the Chemical Industry Award (Verband der Chemischen Industrie e.V.) for best “Abitur” (German high school diploma) in Chemistry

Professional Activities, Memberships

  • 2001 – 2004 Graduate research, Institute of Pharmacology, Freie Universität Berlin, Supervisor: Günter Schultz
  • 2000 Internship, Pharmaceutical R&D, Bayer AG, Leverkusen, Germany

 Publications

  • Plesch E, Chen C-C, Butz E, Scotto Rosato A, Krogsaeter EK, Hua Y, Bartel K, Robaa D, Keller M, Teupser D, Holdt LM, Vollmar AM, Sippl W, Puertollano R, Medina DL, Biel M, Wahl-Schott C, Bracher F, Grimm C#: Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells. eLIFE
  • Chao Y-K, Schludi V, Chen C-C, Butz E, Nguyen, P., Müller, M., Krüger J, Kammerbauer C, Vollmar, A., Berking C, Biel M, Wahl-Schott C Grimm C#: TPC2 polymorphisms associated with a human hair pigmentation phenotype result in gain of channel function by independent mechanisms. PNAS 114:E8595-E8602, 2017.
  • Chen C-C, Butz E, Chao Y-K, Grishchuk Y, Becker L, Heller S, Slaugenhaupt S, Biel M, Wahl-Schott C, Grimm C#: Small molecules for early endosome specific patch-clamping. Cell Chem Biol 24:907-916, 2017.
  • Chen C-C, Chunlei C, Fenske S, Butz E, Chao Y-K, Biel M, Ren D, Wahl-Schott C, Grimm C#: Patch clamp technique to characterize ion channels in individual intact endolysosomes. Nature Protoc 12:1639-1658, 2017.
  • Nguyen P*, Grimm C*, Schneider L, Chao Y-K, Watermann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM: Two-pore channel function is crucial for migration of invasive cancer cells. Cancer Res 77:1427-1438, 2017.
  • Ruas M, Davis LC, Chen C-C, Morgan AJ, Chuang K-T, Walseth TF, Grimm C, Garnham C, Powell T, Biel M, Wahl-Schott C, Parrington J, Galione A: Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J 34:1743-1758, 2015.
  • Sakurai Y, Kolokoltsov AA, Chen C-C, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA: Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment, Science 347:995-998, 2015.
  • Chen C-C, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C#: A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature Commun 5:4681, 2014.
  • Grimm C, Holdt LM, Chen C-C, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C: High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nature Commun 5:4699, 2014.
  • Aneiros E, Cao L, Papakosta M, Stevens EB, Phillips SC, Grimm C#: Biophysical and molecular basis of TRPV1 proton gating. EMBO J 30:994-1002, 2011.
  • Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S: Small molecule activators of TRPML3. Cell Chem Biol (former Chem. & Biol.) 17:135-148, 2010.
  • Grimm C, Cuajungco MP, van Aken AFJ, Schnee M, Jörs S, Kros CJ, Ricci AJ, Heller S: A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. PNAS 104:19583-19588, 2007.

* authors contributed equally; # corresponding or shared corresponding author