Transregional Collaborative Research Centre 152
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Curriculum Vitae

Advanced Professional Positions

  • 2011 – present Group Leader, LMU Munich, Walther-Straub Institute for Pharmacology and Toxicology,
    Head of institute: Thomas Gudermann

Professional Experience and Postdoctoral Training

  • 2010 – 2011 Scientist, The Queen’s Medical Center, Center for Biomedical Research, John A. Burn’s School of Medicine, Honolulu, Hawaii, U.S.A., Head of institute: Reinhold Penner
  • 2007 – 2010 Postdoctoral Fellow, The Queen’s Medical Center, Honolulu, U.S.A, Advisors: Reinhold Penner / Andrea Fleig

Academic Education

  • 2007 PhD thesis (Cell Biology), Dept. of Cell Biology, Paris-Lodron University of Salzburg, Salzburg, Austria
    Mentor: Hubert H. Kerschbaum
  • 2007 Diploma (Biology/Environmental Studies and Mathematics), Dept. of Biology and Mathematics,
    Paris-Lodron University of Salzburg, Salzburg, Austria, Mentors: Hubert H Kerschbaum / Johannes Czermak
  • 2004 Diploma (Biology/Genetics), Dept. of Cell Biology, Paris-Lodron University of Salzburg, Salzburg, Austria,
    Mentor: Hubert H. Kerschbaum

Honours, Awards, Scholarships and Other Qualifications

  • 2012 – 2016 Marie Curie Fellowship, FP7-PEOPLE-2012-CIG grant no. 322185, Research Executive Agency, Brussels, Belgium
  • 2012 DGPT Poster Price awarded by the Naunyn-Schmiedeberg's Archives of Pharmacology, 78th DGPT Congress, Dresden, Germany
  • 2008 – 2010 Postdoctoral Fellowship Grant (Schroedinger Stipend) no. J2784, Austrian Science Fund (FWF), Vienna, Austria
  • 2006 Sackler-Prize (awarded by Mundipharma) at the University of Salzburg, Salzburg, Austria
  • 2006 PENS School, Full Scholarship Award, ‘The Brain as target for inflammatory processes’, Berlin, Germany
  • 2004 – 2006 Doctoral Fellowship Grant (DOC-FFORTE) no. 21686, Austrian Academy of Sciences (OEAW), Vienna, Austria
  • 2002,2004 Academic Excellence Scholarship of the Paris-Lodron University Salzburg, Austria

Professional Activities, Memberships

  • 2013 – present Marie Curie Fellows Association (MCFA)
  • 2011 – present German Society of Experimental and Clinical Pharmacology and Toxicology (DGPT): Society of Pharmacology
  • 2008 – present American Association of Immunologists (AAI)
  • 2004 – 2010 Austrian Neuroscience Association (ANA)
  • 2004 – 2010 Alumni Austrian Academy of Sciences (Alumni/ae ÖAW)

Publications

  • Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti S, Chubanov V, Gudermann T, Grassi F, Zierler S. TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut. Nat Commun, in press, doi: 10.1038/s41467-017-01960-z, 2017.
  • Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi R, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. TRPM7 kinase controls calcium responses in arterial thrombosis and stroke in mice. Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.117.310391. [Epub ahead of print], 2017.
  • Ferioli S, Zierler S, Schredelseker J, Gudermann T, and Chubanov V. TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP. Sci Rep, 7:8806, 2017.
  • Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EPC, Weber C, Yildirim OA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5. pii: e20914. doi: 10.7554/eLife.20914, 2016.
  • Zierler S, Sumoza-Toledo A, Suzuki S, O’Duill F, Ryazanova LV, Penner R, Ryazanov AG, Fleig A. TRPM7 kinase activity regulates murine mast cell degranulation. J Physiol 594, 2957-70, 2016.
  • Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture. Nat Commun 29, 7-11097, 2016.
  • Grossinger, EM, Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmolzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Pinon-Hofbauer J, Hartmann TN, Greil R, Kerschbaum, HH. Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade. Leukemia 28:954-958, 2014.
  • Zierler S, Yao G, Zhang Z, Kuo WC, Porzgen P, Penner R, Horgen FD, Fleig A. Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. J Biol Chem 286:39328-39335, 2011.
  • Lis A*, Zierler S*, Peinelt C, Fleig A, & Penner R. A single lysine in the N terminal region of store-operated channels is critical for STIM1-mediated gating. J Gen Physiol 136:673-686, 2010. *contributed equally to this work
  • Ryazanova LV, Rondon LJ, Zierler S, Hu Z, Galli J, Mazur A, Fleig A, Ryazanov AG. TRPM7 is essential for Mg2+ homeostasis in mammals. Nat Commun 1:109, 2010.