Transregional Collaborative Research Centre 152

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P01 - TRPC1 function in Ca2+ homeostasis

We are studying TRPC1’s molecular properties and systemic functions: We show that the TRPC1-dependent cytoplasmic Ca2+ signature controls the secretion of growth hormone (GH) by pituitary cells, thereby determines GH-related signaling which in turn controls metabolism and body homeostasis. To discriminate between TRPC1’s action on pituitary cells regulating GH/IGF-1 signaling in body homeostasis and its action in peripheral tissues, we will study cell-autonomous functions of TRPC1 employing 2 new mouse strains generated by us. At the same time, we will determine the cell-specific molecular “make-up” of TRPC1 containing protein complexes in close collaboration with P02.

Veit Flockerzi

Prof. Dr. Veit Flockerzi

Saarland University

+49 6841 1626400