Transregional Collaborative Research Centre 152

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Curriculum Vitae

Advanced Professional Positions

  • 2016 – present Director, Department of Pharmacy, LMU Munich, Germany
  • 2009 – 2011 Dean, Faculty of Chemistry and Pharmacy, LMU Munich, Germany
  • 2007 – 2009 Vice Dean, Faculty of Chemistry and Pharmacy, LMU Munich, Germany
  • 2004 – 2006 Director, Department of Pharmacy, LMU Munich, Germany
  • 1999 – present Professor and Chair of Pharmacology, Department of Pharmacy, LMU Munich, Germany
  • 1996 – 1999 ‘Privatdozent’, Institute of Pharmacology and Toxicology, TU Munich, Germany

Professional Experience and Postdoctoral Training

  • 1991 – 1996 Postdoctoral Fellow, TU Munich, Department of Pharmacology and Toxicology, Department head: Franz Hofmann

Academic Education

  • 1996 Habilitation (Pharmacology and Toxicology), TU Munich, Mentor: Franz Hofmann
  • 1987 – 1990 PHD Dissertation (Pharmacy and Physiological Chemistry), Medical School, Saarland University
    Mentors: Franz Hofmann, Joachim Knabe
  • 1983 – 1987 Studies of Pharmacy, Saarland University, Germany

Honours, Awards, Scholarships and Other Qualifications

  • 2013 Feldberg Prize
  • 2011 Phoenix Pharmaceutical Science Award
  • 2007 Phoenix Pharmaceutical Science Award
  • 2004 Honorary Professorship, Fudan University, Shanghai, PR China
  • 1997 Fritz-Winter-Preis, Bayerische Akademie der Wissenschaften
  • 1994 Heinz Maier Leibnitz Forschungsförderungspreis

Professional Activities, Memberships

  • 2014 – present Board Member of the Collaborative Research Center TRR 152
  • 2014 Member of the Bavarian Academy of Sciences
  • 2013 Member of the German Academy of Sciences Leopoldina
  • 2013 Member of the German Academy of Sciences Leopoldina
  • 2010 – present Board Member of the Collaborative Research Center 870
  • 2010 – present Editorial Board, Frontiers in Pharmacology of Ion Channel and Channelopathies
  • 2006 – present Principal Investigator, German National Cluster of Excellence CIPS – M (Center for Integrated Protein Science Munich)
  • 2005 – 2007 Board Member of the Collaborative Research Center 391
  • 2004 – 2008 Editorial Board The Journal of Biological Chemistry


  • Nguyen ON, Grimm C, Schneider L, Chao YK, Watermann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM. Two-pore channel function is crucial for migration of invasive cancer cells. Cancer Res 77:1427-1438, 2017.
  • Fenske S, Pröbstle R, Auer F, Hassan S, Marks V, Pauza D, Biel M, Wahl-Schott C. Comprehensive multi-level in vivo and in vitro Analysis of Heart Rate Fluctuations in mice by ECG telemetry and electrophysiology. Nat Protoc 11: 61-86, 2016.
  • Becirovic E, Böhm S, Nguyen ON, Riedmayr LM, Koch MA, Schulze E, Kohl S, Borsch O, Santos-Ferreira T, Ader M, Michalakis S, Biel M. In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors. PLoS Genet 12:e1005811, 2016.
  • Sakurai Y, Kolokoltsov AA, Chen C-C, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA. Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment. Science 347:995-998, 2015.
  • Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C. A small molecule to restore function of TRPML1 mutant isoforms causing mucolipidosis type IV. Nat Commun 5:4681. doi:10.1038/ncomms5681, 2014.
  • Grimm C, Holdt LM, Chen CC, Hassan S, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Müller C, Spahn S, Castonguay J, Luber CA, Moser M, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C. High Susceptibility to Fatty Liver Disease in Two-pore Channel 2 Deficient Mice. Nat Commun 5:4699. doi:10.1038/ncomms, 2014.
  • Fenske S, Krause S, Hassan S, Becirovic E, Auer F, Bernard R, Kupatt C, Lange P, Ziegler T, Wotjak CT, Zhang H, Hammelmann V, Paparizos C, Biel M, Wahl-Schott C. Sick sinus syndrome in HCN1 deficient mice. Circulation 128:2585-2594, 2013.
  • Fenske S, Mader R, Scharr A, Paparizos C, Cao-Ehlker X, Michalakis S, Shaltiel L, Weidinger M, Stieber J, Feil S, Feil R, Schneider A, Hofmann F, Wahl-Schott CA, Biel M. HCN3 contributes to the ventricular action potential waveform in the murine heart. Circ Res 109:1015-1023, 2011.
  • Zong X, Schieder M, Cuny H, Fenske S, Gruner C, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C. The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores. Pflugers Arch 458:891-899, 2009.
  • Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M. A family of hyperpolarization-activated mammalian cation channels. Nature 393:587-591, 1998.