Transregional Collaborative Research Centre 152
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Curriculum Vitae

Advanced Professional Positions

  • 2011 – present Full Professor, Head Dept. General Pharmacology, Heidelberg University
  • 2004 – 2011 Associate Professor (C3), Experimental Pharmacology and Preclinical Disease Models, University of Saarland and Head of the Transgenic Mouse Facility (SPF) of the Medical Faculty
  • 2000 – 2004 Head of the Research Group „Transgenic mouse models“ at the Department of Experimental and Clinical Pharmacology and Toxicology, University of Saarland

Professional Experience and Postdoctoral Training

  • 1998 – 1999 Postdoctoral Fellow, Department of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Advisor: V. Flockerzi
  • 1996 – 1997 Postdoctoral Fellow, Department of Pharmacology, University of Heidelberg, Advisor: V. Flockerzi

Academic Education

  • 2002 Habilitation (Pharmacology and Toxicology), Saarland University, Mentor: Prof. Dr. V. Flockerzi
  • 1995 Doctor of Medicine, Medical Biochemistry, Saarland University, Mentor: V. Flockerzi
  • 1995 – 1996 “Arzt im Praktikum“, University of Heidelberg, Department of Internal Medicine and Pharmacology (“Approbation“)
  • 1988 – 1994 Medical School at Saarland University

Honours, Awards, Scholarships and Other Qualifications

  • 2002 Alois Lauer Research Grant, University of Saarland
  • 2000 Scholarship of the Novartis-Foundation for Therapeutic Research
  • 1996 von Recklinghausen Award of the German Society of Endocrinology

Professional Activities, Memberships

  • 2012 - present Principal Investigator at the partner site Heidelberg in the “Deutsches Zentrum für Herz-Kreislauf- Forschung e.V. (DZHK)
  • 2012 - present Faculty Member der “Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS)“
  • 2012 - present Member of the Excellence cluster CellNetworks
  • 2011 - present Member of the “Ethikkommission“ of the Medical Faculty, Heidelberg University
  • 2006 - 2011 Member (2009-2011 chairmen) of the animal welfare committe of the Saarland for the evaluation of animal experiments
  • 2006 - 2011 Vice-Chairman of the DFG Graduate School 1326 “Calcium Signaling and Cellular Nanodomains“

Publications

  • Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weissgerber P, Biel M, Philipp S, Freise D, Droogmans G, Hofmann F, Flockerzi V, Nilius B. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol 3, 121-127, 2001.
  • Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M. Reduced cardiac L-type Ca2+ current in CaV2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res 99, 749-57, 2006.
  • Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol 8, 312-20, 2007.
  • Gerzanich V, Woo SK, Vennekens R, Tsymbalyuk O, Ivanova S, Ivanov A, Geng Z, Chen Z, Nilius B, Flockerzi V, Freichel M, Simard JM. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med 15, 185-91, 2009.
  • Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, Camacho Londono JE, Uhl S, Voets T, Hummel B, van den Bergh A, Herijgers P, Nilius B, Flockerzi V, Schweda F, Freichel M. Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J Clin Invest 120, 3267-79, 2010.
  • Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Vennekens R, Wissenbach U, Middendorff R, Flockerzi V, Freichel M. Male fertility depends on Ca2+ absorption by TRPV6 in epididymal epithelia. Sci Signal 4, ra27, 2011.
  • Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA. TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med 18: 1805-11, 2012.
  • Uhl S, Mathar I, Vennekens R, Freichel M. Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice. J Mol Cell Cardiol 74: 307-17, 2014.
  • Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, Laufs U, Birnbaumer L, Flockerzi V, Freichel M*, Lipp P*. A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling. Eur Heart J, 36: 2257 – 66, 2015. *shared senior authorship
  • Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen C, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M. Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J, 36: 2770-2789, 2017.