Transregional Collaborative Research Centre 152

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Curriculum Vitae

Advanced Professional Positions

  • 2010 – present Full Professor (W3), Department of Medicine IV, University Hospital Freiburg, Germany
  • 2010 – 2014 Adjunct Professor, Department of Medicine, Johns Hopkins University School of Medicine
    Baltimore, USA

Professional Experience and Postdoctoral Training

  • 2007 – 2009 Research Associate/Junior Faculty, Department of Biological Chemistry, Johns Hopkins University
    Baltimore, USA, Department head: Gerald Hart
  • 2004 – 2007 Postdoctoral Fellow, Department of Biological Chemistry, Johns Hopkins University, Baltimore, USA, Mentor: Craig Montell
  • 2000 – 2004 Postdoctoral Fellow, Department of Nephrology, University Hospital Freiburg, Germany, Mentor: Gerd Walz
  • 1998 – 2000 Postdoctoral Fellow, Institute of Physiology, University of Freiburg , Germany, Mentor: Rainer Greger
  • 1997 – 1998 Residency, Department of Nephrology, University Hospital Freiburg, Germany, Mentor: Peter Schollmeyer

Academic Education

  • 2007 Habilitation (Experimental Medicine), Albert-Ludwigs-University Freiburg, Germany, Mentor: Gerd Walz
  • 1997 Dr. med. (Physiology), Department of Physiology, Albert-Ludwigs-University Freiburg, Germany, Mentor: Rainer Greger
  • 1997 School of Medicine, Albert-Ludwigs-University Freiburg, Germany

Honours, Awards, Scholarships and Other Qualifications

  • 2015 - present Vice Speaker of the CRC 1140
  • 2009 Offer for tenure track faculty position in the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, USA
  • 2009 German Researcher Relocation Program Award, Alfried Krupp von Bohlen und Halbach Foundation
  • 2009 Cozzarelli Prize, Proceedings of the National Academy of Sciences, USA
  • 2009 Head of the Clinical Research Unit 201, DFG, Germany
  • 2008 Young Investigator Career Development Grant, PKD Foundation, USA
  • 2007 National Kidney Foundation "Young Investigator Award"
  • 2005 PKD Foundation Research Fellowship, USA
  • 1997 Award of the Scientific Society Freiburg for doctoral thesis

Professional Activities, Membership

  • 2007 - present Member of the American Society of Nephrology
  • 2013 - present Associate Editor, Nephron Physiology
  • 2007 - present Member of the American Society of Nephrology
  • 2000 - present Member of the German Physiological Society


  • Hofherr A, Busch T, Huber N, Nold A, Bohn A, Viau A, Bienaime F, Kuehn EW, Arnold SJ, and Köttgen M. Efficient genome editing of differentiated renal epithelial cells. Pflugers Arch 469, 303-311, 2017.
  • Hofherr A, Wagner CJ, Watnick T, and Köttgen M. Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition. Kidney Int 89, 949-955, 2016.
  • Hofherr A, and Köttgen M. Polycystic kidney disease: Cilia and mechanosensation revisited. Nat Rev Nephrol 12, 318-319, 2016.
  • Hofherr A*, Wagner C*, Fedeles S, Somlo S, Köttgen M. N-glycosylation determines the abundance of the transient receptor potential channel TRPP2. J Biol Chem 289:14854-67, 2014.
  • Woodward OM, Tukaye DN, Cui J, Greenwell P, Constantoulakis LM, Parker BS, Rao A, Köttgen M, Maloney PC, and Guggino WB. Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules. Proc Natl Acad Sci USA, 110, 5223-8, 2013.
  • Boehlke C*, Kotsis F*, Patel V*, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Godel M, Muller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, and Kuehn EW. Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol 12, 1115-1122, 2010.
  • Woodward OM*, Köttgen A*, Coresh J, Boerwinkle E, Guggino WB, Köttgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci USA 106, 10338-10342, 2009.
  • Wegierski T*, Steffl D*, Kopp C*, Tauber R, Buchholz B, Nitschke R, Kuehn EW, Walz G, Köttgen M. TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum. EMBO J 28, 490-499, 2009.
  • Köttgen M*, Buchholz B*, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, Walz G. TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182, 437-447, 2008.
  • Köttgen, M*, Benzing T*, Simmen T, Tauber R, Buchholz B, Feliciangeli S, Huber TB, Schermer B, Kramer-Zucker A, Hopker K, Simmen KC, Tschucke CC, Sandford R, Kim E, Thomas G, Walz G: Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J 24, 705-716, 2005.

* shared authorship