Transregional Collaborative Research Centre 152
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Curriculum Vitae

Advanced Professional Positions

  • 2012 Clinical director, Department of Cardiology, Klinikum rechts der Isar, TU Munich, Germany
  • 2006 – present, Full Professor (W2), Klinikum rechts der Isar and Deutsches Herzzentrum, TU Munich, Germany
  • 2005 – present Assistant Professor in Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA (joint appointment)
  • 2000 – present Principal Investigator, Department of Cardiology, Klinikum rechts der Isar and Deutsches Herzzentrum, TU Munich, Germany, Director: Albert Schömig

Professional Experience and Postdoctoral Training

  • 1996 – 2000 Junior Investigator, Department of Cardiology, Klinikum rechts der Isar and Deutsches Herzzentrum, TU Munich, Germany, Director: Albert Schömig

Academic Education

  • 2002 Habilitation (Dr. med. habil. degree), TU Munich
  • 1996 Dr. med., Freie Universität Berlin, Department of Pharmacology, Mentor: Günter Schultz
  • 1988 – 1994 Studies of Medicine, Freie Universität Berlin

Honours, Awards, Scholarships and Other Qualifications

  • 2005 Louis N. Katz Prize of the American Heart Association
  • 2004 Astra-Zeneca Award (Cardiovascular Sciences)
  • 2002-2005 DFG-Heisenberg Scholar at the Institute of Molecular Medicine, University of California San Diego, USA (director: K. Chien)
  • 1998 Merck Sharp Dhome Award (Heart Failure)
  • 1998 Habilitation-Scholarship of the Technische Universität München
  • 1997 Rudolf Buchheim Award, (German Society of Pharmacology and Toxicology)

Professional Activities, Memberships

  • 2010 – present PI member of the Munich Heart Alliance and the German Center for Cardiovascular Research (DZHK)
  • 2006 – present Member of the Harvard Stem Cell Institute (HSCI), Cardiovascular Section, Harvard University, Cambridge, USA
  • 2006 – present Member of the Harvard Stem Cell Institute (HSCI), Cardiovascular Section, Harvard University, Cambridge, USA

Publications

  • Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A*, Laugwitz KL*, Sinnecker D*. Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes. Eur Heart J 38:292-301, 2017. (* corresponding author)
  • Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M. A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. EMBO Mol Med 8:1065-81, 2016.
  • Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL. Embryonic heart progenitors and cardiogenesis. Cold Spring Harb Perspect Med 3:a013847, 2013.
  • Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, Babcock JJ, Bellin M, McManus OB, Tomaselli G, Nan F, Laugwitz K-L, Li M. Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel. Proc Natl Acad Sci USA 109:11866-11871, 2012.
  • Jung CB, Moretti A, Mederos y Schnitzler M, Iop L, Storch U, Bellin M, Dorn T, Ruppenthal S, Pfeiffer S, Goedel A, Dirschinger RJ, Seyfarth M, Lam JT, Sinnecker D, Gudermann T, Lipp P, Laugwitz KL. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol Med 4:180-191, 2012.
  • Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Gödel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz KL. Patient-specific induced pluripotent stem cell models for long-QT syndrome. N Engl J Med 363:1397-409, 2010.
  • Moretti A, Bellin M, Jung CB, Thies T, Takashima Y, Bernshausen A, Schiemann M, Fisher S, Moosmang S, Smith AG, Lam JT, Laugwitz KL. Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. FASEB J 24:700-711, 2010.
  • Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. Islet1 cardiovascular progenitors: a single source for heart lineages? Development 135:193-205, 2008.
  • Moretti A, Caron L, Nakano A, Lam JT, Chen Y, Qyang Y, Sasaki M, Yunfu S, Evans S, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127:1151-1166, 2006.
  • Laugwitz K-L, Moretti A, Lam J, Gruber P, Yinhong Chen, Woodard S, Lin L-Z, Cai C-L, Lu M, Reth M, Platoshyn O, Yuan J, Evans S, Chien KR. Postnatal Isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433:647-653, 2005.