Curriculum Vitae

Advanced Professional Positions

2015 – present Full Professor (W3) and Chair of Regenerative Medicine in cardiovascular Disease, Klinikum rechts der Isar, Klinik und Poliklinik für Innere Medizin I, TU Munich, Germany

2006 – present Group leader, Cardiology Division, First Department of Medicine, Klinikum rechts der Isar
TU Munich, Germany

2005 – 2008 Instructor in Medicine, Cardiovascular Research Center, Massachusetts General Hospital,
Harvard Medical School, Boston, USA, Director: Kenneth R. Chien
2002 – 2005 Project scientist, Institute of Molecular Medicine, University of California San Diego, USA,
Director: Kenneth R. Chien
1997 – 2002 Postdoctoral Fellow, Cardiology Division, First Department of Medicine, Klinikum rechts der Isar, TU Munich, Germany, Director: Albert Schömig

1997 PhD thesis (Pharmacology and Toxicology), Dept. of Biomedical and Experimental Sciences, University of Padua, Padua, Italy, Mentor: Daniela Pietrobon
1992 Diploma (Chemistry and Pharmaceutical Sciences), Dept. of Pharmacology, University of Padua, Padua, Italy, Mentor: Giuliana Fassina

2018 ERC Advanced Grant
2010-present PI member of the Munich Heart Alliance and the German Center for Cardiovascular Research (DZHK)
2010-present Member of the International Society for Stem Cell Research (ISSCR)

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A*, Laugwitz KL*, Sinnecker D*. Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes. Eur Heart J 38:292-301, 2017. (* corresponding author)
Gramlich M, Pane LS, Zhou Q, Chen Z, Murgia M, Schötterl S, Goedel A, Metzger K, Brade T, Parrotta E, Schaller M, Gerull B, Thierfelder L, Aartsma-Rus A, Labeit S, Atherton JJ, McGaughran J, Harvey RP, Sinnecker D, Mann M, Laugwitz KL, Gawaz MP, Moretti A. Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy. EMBO Mol Med 7:562-76, 2015.

Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Guo Y, Kühl SJ, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A. Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity. Stem Cells 33:1113-29, 2015.

Bellin M*, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LGJ, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A*, Mummery CL. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. EMBO J 32:3161-3175, 2013. (* corresponding author)

Moretti A, Laugwitz KL, Dorn T, Sinnecker D, Mummery C. Pluripotent Stem Cell Models of Human Heart Disease. Cold Spring Harb Perspect Med 3 pii: a014027, 2013.

Jung CB*, Moretti A*, Mederos y Schnitzler M, Iop L, Storch U, Bellin M, Dorn T, Ruppenthal S, Pfeiffer S, Goedel A, Dirschinger RJ, Seyfarth M, Lam JT, Sinnecker D, Gudermann T, Lipp P, Laugwitz KL. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol Med 4:180-191, 2012. (* contributed equally)

Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Gödel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz K-L. Patient-specific induced pluripotent stem cell models for long-QT syndrome. N Engl J Med 363:1397-409, 2010.

Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz K-L, Moon RT, Gruber P, Evans SM, Ding S, Chien KR. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/-catenin pathway. Cell Stem Cell 1:1-15, 2007.

Moretti A, Caron L, Nakano A, Lam JT, Chen Y, Qyang Y, Sasaki M, Yunfu S, Evans S, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127:1151-1166, 2006.

Laugwitz K-L*, Moretti A*, Lam J, Gruber P, Yinhong Chen, Woodard S, Lin L-Z, Cai C-L, Lu M, Reth M, Platoshyn O, Yuan J, Evans S, Chien KR. Postnatal Isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433:647-653, 2005. (* contributed equally)