Curriculum Vitae

Advanced Professional Positions

• since 2008 Group leader of the work group “Ca2+-permeable cation channels” at
  Walther Straub Institute of Pharmacology and Toxicology, LMU Munich

Professional Experience and Postdoctoral Training

• since 2018 Coordinator for Clinical Pharmacology and Scientist at Institut für Prophylaxe
  und Epidemiologie der Kreislaufkrankheiten, Klinikum der Universität München,
  LMU Munich (Head: Christian Weber)
• 2015 – 2018 Postdoctoral Fellow, I. Medizinische Klinik und Poliklinik, Klinikum rechts der
  Isar, (Head: Karl-Ludwig Laugwitz)
• 2008 Postdoctoral Fellow at Institut für Pharmakologie und Toxikologie,
  Philipps-Universität Marburg (Head: Thomas Gudermann)

Academic Education

• 2018 Habilitation (Pharmacology), Faculty of Medicine, LMU Munich
• 2008 Dr. rer. nat., Department of Pharmacy, Philipps-Universität Marburg
• 1999 Approbation to practice as a pharmacist
• 1993 – 1998 Studies of Pharmacy, Philipps-Universität Marburg

Honours, Awards, Scholarships and Other Qualifications

• 2018 Poster prize, Deutsche Gesellschaft für Pharmakologie und Toxikologie (DGPT)
• 2014 Poster prize, Deutsche Gesellschaft für Pharmakologie und Toxikologie (DGPT)
  Freiburg

Publications

• Leinders-Zufall T*, Storch U*, Mederos y Schnitzler M, Ojha NK, Koike K, Gudermann T, Zufall F: Diacylglycerol photoswitching as a powerful optical tool in TRP channel research. Star Protocols 2:100527, 2021. * equal contribution
• Erdogmus S*, Storch U*, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos y Schnitzler M: Helix 8 is the essential structural motif of mechanosensitive GPCRs. Nat Commun 10:5784, 2019. *equal contribution
• Leinders-Zufall T, Storch U, Bleymehl K, Mederos y Schnitzler M, Frank JA, Konrad DB, Trauner D, Gudermann T, Zufall F: PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels. Cell Chem Biol 25:215-223.e3, 2018.
• Storch U, Forst AL, Pardatscher F, Erdogmus S, Philipp M, Gregoritza M, Mederos Y Schnitzler M and Gudermann T. Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol. Proc Natl Acad Sci USA 114:E37-E46, 2017.
• Forst AL, Olteanu VS, Mollet G, Wlodkowski T, Schaefer F, Dietrich A, Reiser, J, Gudermann T, Mederos y Schnitzler M and Storch U: Podocyte purinergic P2X4 channels are mechanotransducers that mediate cytoskeletal disorganization. J Am Soc Nephrol 27:848-62, 2016.
• Storch U, Blodow S, Gudermann T, Mederos y Schnitzler M: Cysteinyl leukotriene 1 receptors as novel mechanosensors mediating myogenic tone together with angiotensin II type 1 receptors. Arterioscler Thromb Vasc Biol 35:121-6, 2015.
• Storch U, Forst AL, Philipp M, Gudermann T and Mederos y Schnitzler M: Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. J Biol Chem 287:3530-40, 2012.
• Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, Brandes RP, Grimminger, F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T, Ghofrani HA and Dietrich A: Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun 3:649, 2012.
• Mederos y Schnitzler M*, Storch U*, Meibers S, Nurwakagari P, Breit A, Essin K, Gollasch M and Gudermann T: Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J 27:3092-103, 2008. *equal contribution
• Mederos y Schnitzler M, Gudermann T, Storch U. Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels. Cells 7:218, 2018.