P07 - TRPC channels in synaptic short-term plasticity and secretion
TRPC1, TRPC4 and TRPC5 channels form heteromeric non-selective cation channels, which are highly expressed in brain and neuroendocrine cells. Recently, we identified TRPC channels as crucial regulators of presynaptic Ca2+-dynamics and short-term plasticity. Furthermore, we show that TRPC5 channels play an important role in catecholamine release from mouse chromaffin cells. This project sets out to unravel how TRPCs engage in macromolecular complexes that regulate presynaptic Ca2+-homeostasis, synaptic plasticity and stress-induced catecholamine secretion from neuroendocrine cells.
