Transregional Collaborative Research Centre 152

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P03 - Identification and functional characterization of the TRPP2 channel complex

Mutations in transient receptor potential channel polycystin-2 (TRPP2) cause autosomal dominant polycystic kidney disease (ADPKD). TRPP2 is a Ca2+-permeable non-selective cation channel, but it is not known how TRPP2 channel activity translates into morphogenetic programs. We hypothesize that local Ca2+ signals are critical to regulate specific downstream factors in TRPP2 signaling micro-domains. We have identified novel proteins in the native TRPP2 complex which have revealed a putative mechanism of TRPP2-mediated cell shape regulation. The goal of this proposal is to investigate the function of proteins constituting the native TRPP2 complex in order to understand the role of TRPP2-mediated signaling in health and disease.