Transregional Collaborative Research Centre 152

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P11 - TRPing over TRPM5: Genetic analysis of TRPM5 function in the mouse brain

TRPM5 is an essential signaling component of chemosensory cells, however recent data suggest that it may also be expressed in the central nervous system. To elucidate TRPM5 function within the brain, we have generated a novel knock-in mouse strain and found that TRPM5 is specifically expressed in a subpopulation of tanycytes in the ventricular walls. We will test the hypothesis that peripheral hormonal and other important chemosensory cues are relayed to neighboring hypothalamic nuclei controling energy homeostasis and reproduction via TRPM5-expressing tanycytes.

Ulrich Boehm

Prof. Dr. Ulrich Boehm

Saarland University

+49 6841 1647879