P10 - Novel TRP channel functions in olfaction
The overall goal of this project is to continue to investigate novel functional roles for TRP channels in neuronal processing and homeostatic regulation of the mammalian olfactory system and closely related chemosensory detection systems. This project will focus on TRPC2, TRPM5, TRPM4 and TRPC5. We will investigate the activation mechanisms and second messenger signaling cascades of these channels in various cell types to gain insight into their role in homeostasis. Together, these experiments will provide a concerted effort to discover novel TRP channel functions in the olfactory system and related chemoreceptive systems.