Transregional Collaborative Research Centre 152

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P18 - Drug-like compounds targeting TRP channels

In previous work, we have identified drug-like compounds and lipids as specific modulators of different TRP channels. The proposed project will aim (1) to identify new compounds for TRP channels, for which no suitable inhibitors or activators are commercially available, and optimize existing molecules, (2) to investigate the mechanisms underlying the interactions between compounds and ion channels by biophysical methods, and (3) to evaluate the consequences of channel modulation for (patho)physiological functions of distinct TRP channels in isolated primary cells, tissues, animal models and, within cooperative projects, in isolated organs.