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P17 - Patient-specific induced pluripotent stem cell models to elucidate the role of TRP channels in the pathogenesis of CPVT1 and of PFHBI

Using reprogrammed human pluripotent stem cell derived cardiac myocytes (hiPSC-CMs) and life cell imaging combined with single-cell electrophysiology and UV uncaging we aim at investigating the role of TRPM4 channels in the disease phenotype of inherited cardiac arrhythmia. Functional consequences of pathogenic TRPM4 mutations will be studied at the molecular, cellular, and artificial 3D tissue levels on patient-specific and genetically manipulated hiPSC-CMs of the different ventricular, atrial, and conductive system subtypes.

Karl-Ludwig Laugwitz

Prof. Dr. Karl-Ludwig Laugwitz

Technical University of Munich (TUM)

+49 89 4140 6907

klaugwitz@med1.med.tum.de

Peter Lipp

Prof. Dr. Peter Lipp

Saarland University

+49 6841 162 6103

peter.lipp@uks.eu

Alessandra Moretti

Prof. Dr. Alessandra Moretti

Technical University of Munich (TUM)

+49 89 4140 6907

amoretti@mytum.de