P12 - Control of neuronal and retinal function by two-pore channels
Mice deficient for the endolysosomal TPC2 channel show a strongly reduced susceptibility to laser-induced choroidal neovascularization making TPC2 a prime candidate involved in the pathology of human neovascular (wet) age-related macular degeneration (AMD). In aim 1 retinal cell types expressing TPC2 will be determined. Furthermore, the specific contribution of TPC2 in the control of the intraretinal secretion of proangiogenic factors (aim 2) as well as the migration and activation of mononuclear phagocytes (aim 3) will be examined. In aim 4 the role of the protein Ccz1 in TPC2-mediated retinal neovascularization will be characterized.