Transregional Collaborative Research Centre 152

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P22 - TRPM5: a new target for the resolution of airway inflammation

Recent evidence indicates that bacterial recognition in the respiratory tract involves activation of the transient receptor potential ion channel 5 (TRPM5) in chemosensory brush cells. We aim to functionally characterize the TRPM5 channel in tracheal brush cells in healthy and diseased airways. We will address its role in coupling sensing to mucociliary clearance and to the development of neurogenic inflammation and resolution of airway inflammation. Finally, we want to elucidate the consequences of disturbed mucosal TRPM5 channel function for the outcome in pneumonia. We expect to provide new mechanistic insight into the role of TRPM5 in pathogen recognition and defense, which may offer a new therapeutic strategy to combat respiratory infections.